At Bonitto, we believe that an aesthetic filler should do more than restore volume—it should actively improve the skin’s biological foundation. Our formulation unites BDDE-crosslinked Hyaluronic Acid with L-Proline and Glycine, two essential amino acids fundamental to collagen formation and dermal regeneration.
This advanced synergy delivers immediate shaping with progressive skin rejuvenation, ensuring results that are natural, durable, and clinically meaningful.
Bonitto fillers are manufactured using BDDE cross-linking technology, forming stable ether bonds known for their low toxicity and long-term durability. This reaction creates a three-dimensional “spiderweb-like” HA matrix, a structural hallmark of high-quality, cross-linked hydrogels.
Scientifically, this matrix exhibits:
These rheological properties translate to real clinical benefits:
predictable lifting, shape retention, and harmonious integration into facial tissue.
While the HA-BDDE network provides mechanical stability, the addition of L-Proline and Glycine introduces a powerful biological advantage.
1. Collagen Stimulation
As the primary building blocks of collagen, these amino acids support fibroblast activity and encourage new collagen synthesis around the implanted filler. This enhances firmness and improves dermal density over time.
2. Enhanced Tissue Integration
The optimized ECM environment promotes smoother blending between the filler and surrounding tissues, reducing the risk of irregularities and providing a more natural touch and appearance.
3. Long-Term Reinforcement
By supporting ECM regeneration, L-Proline and Glycine help maintain volumizing effects for longer, complementing the chemical longevity of BDDE ether bonds.
4. Skin Recovery & Comfort
These amino acids participate in wound-healing pathways and modulate micro-inflammation, promoting a gentler injection experience and improved post-treatment comfort.
Bonitto fillers combine two powerful mechanisms:
Structural Action (BDDE Crosslinking)
Biological Action (L-Proline + Glycine)
The result: A filler that not only shapes but actively rejuvenates.
Bonitto delivers the ideal combination of precision, performance, and patient satisfaction.
Bonitto fillers combine BDDE-crosslinked Hyaluronic Acid with L-Proline and Glycine to deliver durable volume, superior elasticity, and enhanced collagen regeneration. The unique “spiderweb-like” HA matrix ensures excellent tissue integration and long-lasting results, while amino acid enrichment improves dermal quality, firmness, and post-treatment comfort.